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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 9, No. 2, 2012, pp. 228-233
Bioline Code: tc12030
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 9, No. 2, 2012, pp. 228-233

 en SPASMOLYTIC EFFECTS OF AQUEOUS EXTRACT OF MIXTURE FROM AFRAMOMUMUM MELEGUETA check for this species in other resources (K SCHUM) – CITRUS AURANTIFOLIA check for this species in other resources (CHRISTM AND PANZER) ON ISOLATED TRACHEA FROM RAT
Ahounou, Judith. F.; Ouedraogo, Geoffroy G.; Gbenou, Joachim D.; Ouedraogo, Sylvin; Agbodjogbe, Wilfrid K.D.D.; Dansou, Pierre H. & Moudachirou, Mansourou

Abstract

The spasmolytic properties of the aqueous extract of Aframomum melegueta check for this species in other resources (K Schum) and Citrus aurantifolia check for this species in other resources (Christm and Panzer) (AMCA) mixture were tested on isolated rat trachea. Inhibition of the contraction was observed the in presence of the AMCA (EC 50 = 1.80 ± 0.48 mg/mL) after a pre contraction of the trachea by acetylcholine (10 -5 M). With propranolol (10 -6 M), the spasmolytic activity of the mixture was inhibited and the concentration-response curve shifted to the right. The EC50 value was then 2.60 ± 0.41 mg/mL. AMCA also inhibited contraction induced by KCl (4.10 -2 M) with EC50 value = 1.86 ± 0.65 mg/mL. These results clearly show the relaxing effect of the aqueous extract on the isolated rat trachea. This effect involved some β-adrenergic receptor inhibition.

Keywords
Aframomum melegueta; Citrus aurantifolia; extract; bronchodilatory; spasmolytic; Rat trachea

 
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