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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 9, No. 2, 2012, pp. 250-255
Bioline Code: tc12033
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 9, No. 2, 2012, pp. 250-255

 en ANTI-INFLAMMATORY ACTIVITY OF CRUDE SAPONIN EXTRACTS FROM FIVE NIGERIAN MEDICINAL PLANTS
Hassan, H S; Sule, M I; Musa, A M; Musa, K Y; Abubakar, M S & Hassan, A S

Abstract

Crude saponin extracts of five medicinal plants used in the treatment of inflammatory diseases like rheumatoid arthritis, gout and haemorrhoids were screened for anti-inflammatory activity using carrageenan-induced rat paw oedema test. These plants were the whole plant of Schwenkia americana check for this species in other resources Linn (WSA), the rhizomes of Asparagus africanus check for this species in other resources Lam (RAA), the leaves of Dichrostachys cinerea check for this species in other resources Linn (LDC), the stem bark of Ficus iteophylla check for this species in other resources Miq (BFI) and the leaves of Indigofera pulchra check for this species in other resources Willd (LIP). A modify traditional method of crude saponins extraction was used to give the following percentage yields: WSA-2.74%, RAA- 3.59%, LDC-1.62%, BFI-0.81% and LIP-1.57% respectively. Thin-layer chromatography was used to identify the type of saponins present in the extracts. The acute toxicity study of the crude saponin extracts in mice gave the following intraperitoneal LD50: WSA-471.2mg/kg, RAA- 1264.9mg/kg, LDC-1264.9mg/kg, BFI-118.3mg/kg and LIP-1264.9mg/kg respectively. The antiinflammatory study of the extracts showed statistically significant (P<0.05) decreases in the rat paw-oedema as compared to the control. The percentage inhibitions of the extracts after four hours were as follow: WSA-61%, RAA-55%, LDC-72%, BFI-66% and LIP-40% respectively. These values were found to be comparable to that of ketoprofen-63%. The study showed that the antiinflammatory properties attributable to these plants may be due to their saponins contents.

Keywords
Asparagus africanus; Dichrostachys cinerea; Ficus iteophylla; Indigofera pulchra; Schwenkia americana; Saponin; Anti-inflammatory activity; Carrageenan; TLC

 
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