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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 9, No. 2, 2012, pp. 271-276
Bioline Code: tc12038
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 9, No. 2, 2012, pp. 271-276

 en ANTI-INFLAMMATORY, ANTIOXIDANT, AND SELECTIVE ANTIBACTERIAL EFFECTS OF EUADENIA EMINENS check for this species in other resources ROOT BARK
Dickson, RA; Fleischer, TC; Ekuadzi, E & Komlaga, G.

Abstract

Euadenia eminens check for this species in other resources Hook f. (Capparaceae) has traditional uses in the management of conjunctivitis, iritis, ophthalmia, tuberculosis, otalgia and rectal prolapse. The fruit pulp is also eaten as an aphrodisiac. In this paper, we report on the antiinflammatory, antioxidant and antibacterial effects of its roots. A 70 % ethanol extract was tested for anti-inflammatory effect using the carrageenan-induced oedema in chicks. Free radical scavenging, total antioxidant and total phenol content were assessed spectrophotometrically. The extract was tested for antibacterial activity using the agar well diffusion method and micro dilution assays. The 70% ethanol extract gave a maximal inhibition of oedema by 74.18 % at 30 mg/kg. The total antioxidant capacity expressed in terms of ascorbic acid was 0.609 mg/g dry weight. The total phenol in terms of tannic acid was 7.25 mg/g dry weight. The extract also demonstrated free radical scavenging activity yielding IC50 value of 1.175 mg/mL. The root extract however, showed selective antibacterial activity, inhibiting growth of two microorganisms; Bacillus subtilis check for this species in other resources and Bacillus thurigiensis check for this species in other resources . The MICs were 500 and 1000 μg/mL respectively. These results may account in part for the ethnopharmacological use of the plant.

Keywords
Anti-infective; Anti-inflammatory; Antioxidant; Carrageenan-induced oedema; Euadenia eminens

 
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