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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 9, No. 3, 2012, pp. 323-328
Bioline Code: tc12044
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 9, No. 3, 2012, pp. 323-328

 en ANTIMICROBIAL ACTIVITY OF CARPOLOBIA LUTEA check for this species in other resources EXTRACTS AND FRACTIONS
Nwidu, Lucky L.; Nwafor, Paul A. & Vilegas, Wagner

Abstract

Carpolobia lutea check for this species in other resources (G. Don) (Polygalaceae) is a tropical medicinal plant putative in traditional medicines against gonorrhea, gingivitis, infertility, antiulcer and malaria. The present study evaluated the antimicrobial, antifungal and antihelicobacter effects of extracts C. lutea leaf, stem and root. The extracts were examined using the disc-diffusion and Microplates of 96 wells containing Muller-Hinton methods against some bacterial strains: Eschericia coli check for this species in other resources (ATCC 25922), E. coli (ATCC10418), Pseudomonas aeruginosa check for this species in other resources (ATCC 27853), Staphylococcus aureus check for this species in other resources (ATCC 25923), Staphyllococus aureus check for this species in other resources (ATCC 6571), Enterococcus faecalis check for this species in other resources (ATCC 29212) and Bacillus subtilis check for this species in other resources (NCTC 8853) and four clinical isolates: one fungi (Candida albican check for this species in other resources ) and three bacteria (Salmonella check for this species in other resources , Sheigella check for this species in other resources and staphylococcus aureus). The Gram-positive bacteria: Staphylococcus aureus (ATCC 25923), Enterococcus faecalis (ATCC 29212), Bacillus subtilis (ATCC 19659) and the Gram-negative bacteria: Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Cândida albicans (ATCC 18804) and Helicobacter pylori check for this species in other resources (ATCC 43504). Some of these extracts were found to be active against some tested strains but activity against H. pylori was >1000mg/ml and good fungistatic activity against C. albican. The MIC against C. albican is in the order n-HF > CHF > ETF= EAF.The order of potency of fraction was the ethanol root > n-HF leaf > ethanol fraction stem > chloroform fraction leaf = ethyl acetate fraction leaf. Polyphenols were demonstrated in ethanol fraction, ethyl acetate fraction, crude ethyl acetate extract and ethanol extract, respectively. These polyphenols isolated may partly explain and support the use of C. lutea for the treatment of infectious diseases in traditional Ibibio medicine of Nigeria.

Keywords
Carpolobia lutea; Polygalaceae; antimicrobial; antifungal; antihelicobacter; Polyphenols

 
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