Toxicity tests of 95% ethanol extract of the root of Antidesma acidum
were studied in male and female rats. The
oral acute toxicity test at 5,000 mg/kg revealed that the ethanol extract did not produce toxic effects on signs, general
behavious, mortality and gross appearance of internal organs of rats. Furthermore, the oral sub-acute toxicity test at the dose
of 1,000 mg/kg/day displayed no significant changes in body and internal organs’ weights, normal hematological and clinical
blood chemistry values. Histological examination also showed normal architecture of all internal organs. In conclusion, the
ethanol extract of Antidesma acidum
did not produce any toxicity in oral acute and suba-cute toxicity studies.