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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 9, No. 4, 2012, pp. 465-469
Bioline Code: tc12078
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 9, No. 4, 2012, pp. 465-469

 en EVALUATION OF ACUTE AND SUBACUTE ORAL TOXICITY OF THE ETHANOL EXTRACT FROM ANTIDESMA ACIDUM check for this species in other resources RETZ.
Sireeratawong, Seewaboon; Thamaree, Sopit; Ingkaninan, Kornkanok; Piyabhan, Pritsana; Vannasiri, Supaporn; Khonsung, Parirat; Singhalak, Tipaya & Jaijoy, Kanjana

Abstract

Toxicity tests of 95% ethanol extract of the root of Antidesma acidum check for this species in other resources were studied in male and female rats. The oral acute toxicity test at 5,000 mg/kg revealed that the ethanol extract did not produce toxic effects on signs, general behavious, mortality and gross appearance of internal organs of rats. Furthermore, the oral sub-acute toxicity test at the dose of 1,000 mg/kg/day displayed no significant changes in body and internal organs’ weights, normal hematological and clinical blood chemistry values. Histological examination also showed normal architecture of all internal organs. In conclusion, the ethanol extract of Antidesma acidum did not produce any toxicity in oral acute and suba-cute toxicity studies.

Keywords
Antidesma acidum; Acute toxicity; Subacute toxicity

 
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