The Chinese herbal formula consisting of Astragalus membranaceus
, Epimedium brevicornum
Paeoniae Alba Radix
and Radix Ophiopogonis
in proper proportions were adopted in order to investigate the
immunoenhancing properties of the herbal formula. Fifty ICR mice were randomly divided into 5 groups (NS, NS+Hy, L+Hy, M+Hy, H+Hy). The mice in hydrocortisone (Hy) groups were injected with hydrocortisone i.p.
to induce the immunosuppressive condition. The mice in group NS were administered with normal saline as
controls. The mice in groups NS+Hy, L+Hy, M+Hy, H+Hy were administered with normal saline, low,
moderate and high dose of the herbal prescription respectively by gavage for 6 days. The level of serum
hemolysin, the function of antibody function cell (AFC) and CD4+
T cell ratio were measured at the end of
experiments. The results showed that the level of serum hemolysin, the function of AFC and CD4+
ratio in L+Hy, M+Hy, H+Hy groups increased significantly compared with those in NS or NS+Hy groups. These
results indicate that Chinese herbal medicine prescription can enhance humoral immunity and cellular immune
function of the immunosuppressivemouse.