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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 9, No. 4, 2012, pp. 607-611
Bioline Code: tc12094
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 9, No. 4, 2012, pp. 607-611

 en ACUTE TOXICITY OF OPUNTIA FICUS INDICA check for this species in other resources AND PISTACIA LENTISCUS check for this species in other resources SEED OILS IN MICE
Boukeloua, A.; Belkhiri, A.; Djerrou, Z.; Bahri, L.; Boulebda, N. & Pacha, Y. Hamdi

Abstract

Opuntia ficus indica check for this species in other resources and Pistacia lentiscus check for this species in other resources L. seeds are used in traditional medicine. The objective of this study was to investigate the toxicity of the fixed oil of Opuntia ficus indica and Pistacia lentiscus L. seeds in mice through determination of LD50 values, and also the physicochemical characteristics of the fixed oil of these oils. The acute toxicity of their fixed oil were also investigated in mice using the method of Kabba and Berhens. The fixed oil of Pistacia lentiscus and Opuntia ficus indica seeds were extracted and analyzed for its chemical and physical properties such as acid value, free fatty acid percentage (% FFA), iodine index, and saponification value as well as refractive index and density. LD50 values obtained by single doses, orally and intraperitoneally administered in mice, were respectively 43 ± 0,8 ;[40.7- 45.4 ] ml/kg body wt. p.o. and 2.72 ± 0,1 ;[2.52–2.92] ml/kg body wt. i.p. for Opuntia ficus indica ; and 37 ± 1 ;[34.4 – 39.8 ] ml/kg body wt. p.o. and 2.52 ± 0,2 ;[2.22 – 2.81 ] ml/kg body wt. i.p. for Pistacia lentiscus respectively. The yields of seed oil were respectively calculated as 20.25% and 10.41%. The acid and free fatty acid values indicated that the oil has a low acidity

Keywords
Opuntia ficus indica L.; Pistacia lentiscus L.; seed oil; acute toxicity.

 
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