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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 1, 2013, pp. 166-169
Bioline Code: tc13022
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 1, 2013, pp. 166-169

 en ACARBOSE: A NEW OPTION IN THE TREATMENT OF ULCERATIVE COLITIS BY INCREASING HYDROGEN PRODUCTION
Zhang, De-Qing; Zhu, Jian-Hong & Chen, Wei-Chang

Abstract

Acarbose,which is clinically widely used to treat Type 2 Diabetes,is thought to act at the small intestine by competitively inhibiting enzymes that delay the release of glucose from complex carbohydrates, thereby specifically reducing post prandial glucose excursion. The major side-effect of treatment with acarbose, flatulence, occurs when undigested carbohydrates are fermented by colonic bacteria, resulting in considerable amount of hydrogen. We propose that enteric benefits of acarbose is partly attributable to be their ability to neutralise oxidative stress via increased production of H2 in the gastrointestinal tract. Therefore, symptoms of ulcerative colitis in human beings can be ameliorated by acarbose.

Keywords
acarbose; ulcerative colitis; hydrogen

 
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