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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 2, 2013, pp. 251-257
Bioline Code: tc13031
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 2, 2013, pp. 251-257

 en EXTRACT OF PERILLA FRUTESCENS check for this species in other resources INHIBITS TUMOR PROLIFERATION OF HCC VIA PI3K/AKT SIGNAL PATHWAY
Wang, Ying; Huang, Xiaoxu; Han, Jianming; Zheng, Wenling & Ma, Wenli

Abstract

In this study, isoegomaketone(IK) was isolated from Perilla frutescens check for this species in other resources (L.), a Chinese herbal. The effects of IK were examined by cell viability assay, colony formation assay, xenograft tumor assay and western blotting in HCC cells. We found that IK inhibited cell viability, and its administration decreased tumor volume and weight profoundly. The presence of IK(10nmol/l) produced a dramatic decrease of pAkt, while total Akt level was not affected. The data suggested that IK from perilla suppressed HCC tumor growth via blocking PI3K/Akt signaling pathway.

Keywords
Perilla Frutescens; IK; Tumor Proliferation; HCC; PI3K/AKT

 
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Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam

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