search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 3, 2013, pp. 410-417
Bioline Code: tc13051
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 3, 2013, pp. 410-417

 en USE OF ANTIFUNGAL SAPONIN SC-2 OF SOLANUM CHRYSOTRICHUM check for this species in other resources FOR THE TREATMENT OF VULVOVAGINAL CANDIDIASIS: IN VITRO STUDIES AND CLINICAL EXPERIENCES
Herrera-Arellano, Armando; López-Villegas, Edgar O.; Rodríguez-Tovar, Aida V.; Zamilpa, Alejandro; Jiménez-Ferrer, Enrique; Tortoriello, Jaime & Martínez-Rivera, M. Angeles

Abstract

Saponin SC-2 from Solanum chrysotrichum check for this species in other resources showed antifungal activity, demonstrated in vitro, which inhibited the growth of dermatophytes, and in vivo, to be effective in the treatment against tinea pedis and pityriasis capitis. Fungistatic and fungicidal activity of saponin SC-2 on Candida albicans check for this species in other resources and other Candida check for this species in other resources species, fluconazole and ketoconazole resistaent strains was demostrated. SC-2-associated ultrastructural alterations in several Candida species were observed. An exploratory clinical, randomized, double-blind, and controlled ketoconazole study of ketoconazole was conducted with the aim of assessing the effectiveness and tolerability of an herbal medicinal product containing SC-2, on women with Vulvovaginal candidiasis (VVC). The results exhibited a percentage of therapeutic clinical effectiveness similar to that of ketoconazole (X2, p ≥0.30), but obtained a smaller percentage of mycological effectiveness, and 100% tolerability. In conclusion, saponin SC-2 possesses fungicidale and fungistatic activity on Candida albicans and other multi resistant Candida species, causes morphological changes and fungal death, and it is an alternative therapy for the treatment of VVC.

Keywords
Solanum chrysotrichum; saponins; antifungal activity; vulvovaginal candidiasis; alternative therapy

 
© African Journal of Traditional, Complementary and Alternative Medicines
Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2017, Site last up-dated on 05-Dec-2017.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil