The current study was undertaken to evaluate
in vitro the antileishmanial activity of three plants growing wild in Algeria :
Juglans regia
,
Lawsonia inermis
and
Salvia officinalis
. The hydroalcoholic extracts of these plants were tested on the growth of the promastigotes of
Leishmania major. The plant extract effects were compared with three controls : CRL1 composed of 1 ml RPMI inoculated with 10
6 of promastigotes, CRL2 composed of 1 ml RPMI inoculated with 10
6 of promastigotes and 100 μl of hydroalcoholic solvent, CRL3 composed of 1 ml RPMI inoculated with 10
6 of promastigotes and 100 μl of Glucantim as a reference drug in the management of leishmaniasis. The results showed that both
J. regia and
L. inermis extracts reduced the promastigotes number significantly (P<0.01). however,
S. officinalis showed a total inhibition of the
Leishmania major growth.
