As the traditional Chinese medicine, the fresh fruits of
Amorpha fruticosa
L. were applied for the treatment of carbuncle, eczema and burn (Das et al., 2007). However, little is known about the functional roles of the fruits of
Amorpha fruticosa L. during wound healing progress. In the present study, we evaluated both antimicrobial potential against a wide range of microorganisms and wound healing activity of the seven compounds isolated from the fruits of
Amorpha fruticosa L
in vitro and
in vivo. Our results showed that compounds I (6a,12a–dehydroamorphin), V (dehydrosermundone) and VI (tephrosin) isolated from the fruits of
Amorpha fruticosa L. performed dominant antimicrobial potential against microorganisms. Moreover, these compounds significantly enhanced fibroblasts proliferation and migration, leading to promotion of wound healing. Thus, it could be possible for the therapeutic utilization of
Amorpha fruticosa L. for wound healing in the future.
