We evaluated the
in vitro and
in vivo inhibition of S
180 tumor cell growth of the water extract of
Agrimonia pilosa
. Inhibitory effect of
Agrimonia pilosa on
in vitro-cultured S
180 cell proliferation was measured by MTT assay; mice model of transplanted tumor was established, after 8 days of continuous administration, the tumors were removed, weighed, and compared with the control group, and the
in vivo anti-tumor effect of
Agrimonia pilosa on mouse sarcoma S
180 was compared using inhibition rate. The
in vitro anti-tumor experiment indicated that the inhibition rate gradually increases with the increase of extract concentration and the extension of time, with IC
50 175.64, 90.59, and 71.74 μg/ml at 24 h, 4 h, and 72 h respectively. In this study, the
in vitro MTT assay was used to determine the inhibitory effect of
Agrimony pilosa water extract on S
180 tumor cells, the method is simple, reliable, and practical; mice model of
in vivo transplanted S
180 tumor was established, which allowed direct observation of tumor inhibitory effect, and thus found out that the water extract of
Agrimonia pilosa has inhibitory effect on S
180 tumor cells.
