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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 3, 2013, pp. 580-585
Bioline Code: tc13076
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 3, 2013, pp. 580-585

 en STUDY ON ANTI-TUMOR EFFECT OF TOTAL GLYCOSIDES FROM RADIX PAEONIAE RUBRA IN S180 TUMOR-BEARING MICE
Xu, Wanpeng; Zhong, Wei; Liu, Jinlan; Liu, Hong & Zhu, Bing

Abstract

The objective of the paper was to study the anti-tumor effect of total glycosides from Radix paeoniae rubra in S180 tumor-bearing mice, and to preliminarily explore its mechanism of action. Mice were made into S180 solid tumor model, grouped and administered with the extracts; tumor inhibition rate was measured by harvesting the tumors, and serum IL-2 and IL-4 levels were measured by taking blood samples. Total glycosides of Radix paeoniae rubra significantly inhibited the growth of tumor cells in tumor-bearing organisms, enhanced the cytotoxic activity of NK cells, and increased the serum IL-2 and IL-4 levels. Total glycosides of Radix paeoniae rubra have some anti-tumor effect in vivo, which might have been accomplished through the regulation of the immune system.

Keywords
total glycosides of Radix Paeoniae Rubra; S180 sarcoma; IL-2; IL-4

 
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