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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 4, 2013, pp. 6-11
Bioline Code: tc13078
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 4, 2013, pp. 6-11

 en EFFECT OF FOUR MEDICINAL PLANTS ON AMYLOID-β INDUCED NEUROTOXICITY IN SH- SY5Y CELLS
Adewusi, Emanuel A.; Fouche, Gerda & Steenkamp, Vanessa

Abstract

Amyloid-beta peptide (Aβ) is implicated in the pathogenesis of Alzheimer’s disease (AD), a neurodegenerative disorder. This study was designed to determine the effect of four medicinal plants used to treat neurodegenerative diseases on Aβ- induced cell death. Cytotoxicity of the ethanol extracts of the plants was determined against SH-SY5Y (human neuroblastoma) cells which were untreated, as well as toxically induced with Aβ, using the MTT and neutral red uptake assays. Cell viability was reduced to 16% when exposed to 20 μM Aβ25-35 for 72 h. The methanol extract of the roots of Ziziphus mucronata check for this species in other resources Willd., Lannea schweinfurthii check for this species in other resources (Engl.) Engl. and Terminalia sericea check for this species in other resources Burch. ex DC., were the least toxic to the SH-SY5Ycells at the highest concentration tested (100 μg/ml). All four plants tested were observed to reduce the effects of Aβ-induced neuronal cell death, indicating that they may contain compounds which may be relevant in the prevention of AD progression.

Keywords
Amyloid-beta peptide; medicinal plants; neurodegenerative disorders; neurotoxicity; SH-SY5Y cells

 
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