THE EFFECTS OF β-ELEMENE ON THE EXPRESSION OF MTOR, HIF-1Α, SURVIVIN IN LUNG ADENOCARCINOMA A549 CELL

The purpose of this manuscript was to study the regulation effects of β-elemene combined with radiotherapy on three different gene expressions in lung adenocarcinoma A549 cell. mTOR gene, HIF-1α gene, Survivin gene were included in the gene group. Cell culture and RT-PCR were applied to finish this research. Hypoxia Control group, Hypoxia β-elemene group, Hypoxia β-elemene combined with were set to compare the differences of three different gene expressions. The most active effects β-elemene. In this group, the mTOR gene, HIF-1α gene, Survivin gene expressions were all down-regulated when compared with the single treatment groups, and there were significantly statistical differences.