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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 4, 2013, pp. 18-23
Bioline Code: tc13080
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 4, 2013, pp. 18-23

 en THE EFFECTS OF β-ELEMENE ON THE EXPRESSION OF MTOR, HIF-1Α, SURVIVIN IN LUNG ADENOCARCINOMA A549 CELL
Tong, Enjuan; Xu, Yinghui; Li, Guoquan; Zou, Kun & Zou, Lijuan

Abstract

The purpose of this manuscript was to study the regulation effects of β-elemene combined with radiotherapy on three different gene expressions in lung adenocarcinoma A549 cell. mTOR gene, HIF-1α gene, Survivin gene were included in the gene group. Cell culture and RT-PCR were applied to finish this research. Hypoxia Control group, Hypoxia β-elemene group, Hypoxia β-elemene combined with were set to compare the differences of three different gene expressions. The most active effects β-elemene. In this group, the mTOR gene, HIF-1α gene, Survivin gene expressions were all down-regulated when compared with the single treatment groups, and there were significantly statistical differences.

Keywords
β-elemene; A549; mTOR; HIF-1α; Survivin; Rhizoma Curcumae

 
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