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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 4, 2013, pp. 41-46
Bioline Code: tc13083
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 4, 2013, pp. 41-46

 en STUDY ON THE EFFECT OF POLYSACCHARIDES FROM SOLANUM NIGRUM LINNE check for this species in other resources ON CELLULAR IMMUNE FUNCTION IN TUMOUR-BEARING MICE
Chen, Hai & Qi, Xiaodong

Abstract

We investigated the anti-tumour effect of polysaccharides from Solanum nigrum Linne check for this species in other resources , and its relationship with the immune function of tumour-bearing organisms. MTT assay was used to observe the effect of different doses of polysaccharides from Solanum nigrum Linne on proliferation of lymphocytes in tumour-bearing mice. ELISA assay was also used to detect the levels of IL-2 in mice, and a laser scanning confocal microscope was used to detect the effect of polysaccharides from Solanum nigrum Linne on intralymphocytic free calcium ion concentration in tumour-bearing mice. Different doses of polysaccharides from Solanum nigrum Linnesignificantly inhibited the growth of mouse H22 solid tumours, improved the survival time of tumour-bearing mice, increased the proliferation of lymphocytes, elevated the levels of IL-2, and increased the concentration of calcium ions in the lymphocytes. Polysaccharides from Solanum nigrum Linne have certain anti-tumour effect, which is related with the cellular immune function that regulates the body.

Keywords
Solanum nigrum polysaccharides; tumour-bearing mice; cellular immunity

 
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