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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 4, 2013, pp. 66-69
Bioline Code: tc13087
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 4, 2013, pp. 66-69

 en THE INHIBITORY EFFECT OF BINENS BIPINNATA L. check for this species in other resources EXTRACT ON U14 TUMOUR IN MICE
Zhu, Li-Hong; Qin, Rui-Ying; Guo, Hui-Min; Ding, Xiao-Li; Guan, Xin-Lei; Liu, Shan-Shan & Pan, Ying

Abstract

The objective of this paper was to study the in vitroand in vivo inhibitory effect of Bidens bipinnata L. check for this species in other resources extract on growth of cervical carcinoma U14 cells. MTT method was used to determine the inhibitory effect of Bidens bipinnata L. extract on U14 tumour cells, and the effects of Bidens bipinnata L. extract on inhibition rate of solid tumour and life prolongation rate of ascites tumour were observed through the establishment of two animal models of mouse cervical carcinoma U14 solid tumour and ascites tumour. In the in vitro MTT assay, the inhibition rate gradually increased with the increase of dose of Bidens bipinnata L. and the extension of time. Its inhibition rate was 70.44% at a concentration of 80μg/L. Solid tumour inhibition rates in the high- and low-dose groups and cisplatin group were 49.13%, 2.26% and 75.72% respectively; life prolongation rates in each ascites tumour group were 63.63%, 34.86% and 87.34% respectively. The Bidens bipinnata L. extract has a certain inhibitory effect on growth of mouse cervical carcinoma U14.

Keywords
Bidens bipinnata L. extract; U14; solid tumour; ascites tumour

 
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