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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 4, 2013, pp. 94-100
Bioline Code: tc13092
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 4, 2013, pp. 94-100

 en EVALUATION OF ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC EFFECTS OF ETHANOLIC EXTRACT OF PEDALIUM MUREX LINN. check for this species in other resources FRUITS
Patel, Mahendra K.; Mandavia, Divyesh R.; Patel, Tejas K.; Barvaliya, Manish J. & Tripathi, C. B.

Abstract

This study investigated the possible anti-inflammatory, analgesic, and antipyretic effects of ethanolic extract of Pedalium murex Linn. check for this species in other resources fruits in selected experimental animal models. Anti-inflammatory activity of Pedalium murex Linn., with doses of 200 mg/kg and 400 mg/kg, p.o., was evaluated by Lambda-carrageenan induced paw oedema in Wistar albino rats; analgesic activity with doses of 280 mg/kg and 560 mg/kg, p.o., was evaluated by hot plate method and acetic acid induced writhing method in Swiss albino mice; and antipyretic activity with doses of 110 mg/kg and 220 mg/kg, p.o., was evaluated in New Zealand white rabbits by injecting gram –ve lipopolysaccharide obtained from E. coli. Results were analysed by one way ANOVA followed by Dunnet’s multiple comparison test. Pedalium murex Linn. showed significant anti-inflammatory activity from 15 min to 180 min as compared to vehicle treated animals. It was comparable to diclofenac sodium at 180 min. The extract did not prolong the reaction time on hot plate method but significantly reduced the number of writhing after acetic acid administration. Also the extract did not show any antipyretic activity on lipopolysaccharide induced pyrexia. It is therefore concluded that the ethanolic extract of Pedalium murex Linn. fruits has an anti-inflammatory and peripheral analgesic effects.

Keywords
Anti-inflammatory; Analgesic; Antipyretic,; Pedalium murex Linn.; Carrageenan

 
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