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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 5, 2013, pp. 283-291
Bioline Code: tc13116
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 5, 2013, pp. 283-291

 en IN VITRO ANTI-OXIDATIVE ACTIVITIES OF THE VARIOUS PARTS OF PARKIA BIGLOBOSA check for this species in other resources AND GC-MS ANALYSIS OF EXTRACTS WITH HIGH ACTIVITY
Ibrahim, M.A.; Koorbanally, N.A. & Islam, M.S.

Abstract

The anti-oxidative activities of sequentially extracted solvent fractions of different parts of P. biglobosa check for this species in other resources were evaluated in a series of in vitro assays. Our findings indicated that all extracts had electron donating and free radical scavenging activities. But the ethanol (EtOH) extracts from all the parts demonstrated more promising anti-oxidative effects in these experimental models. Apart from the aqueous extracts of the stem bark and leaves, all other extracts exhibited hydroxyl radical scavenging (HRS) activity but the ethyl acetate (EtOAc) extract of the stem bark and EtOH extracts of the root and leaves possessed more powerful HRS activity than other corresponding extracts in the parts. Further, nitric oxide (NO) inhibition activities were observed in all the extracts except the EtOAc extract of the stem bark which showed pro- oxidative activity. However, the EtOH extract of the stem bark and root as well as the EtOAc extract of the leaves displayed more potent anti-NO activity than other extracts in the parts. The GC-MS analysis of the EtOH extracts revealed that the most abundant phytochemicals are pyrogallol derivatives. Data from this study suggest that the EtOH extracts from different parts of P. biglobosa contained potent anti-oxidative agents and pyrogallol could be the main bioactive constituent.

Keywords
Anti-oxidative; free radicals; GC-MS; Parkia biglobosa; pyrogallol

 
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