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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 5, 2013, pp. 310-312
Bioline Code: tc13120
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 5, 2013, pp. 310-312

 en A STUDY ON THE PROTECTIVE EFFECT OF SILYBUM MARIANUM check for this species in other resources EXTRACT ON HEPATIC ISCHEMIA-REPERFUSION INJURY
Liu, Shaojun; Chen, Zhiheng; Cao, Dongbo; Liu, Fen; Wang, Xiaoyan; Zhao, Lian; Liu, Rui & Xiao, Zhiming

Abstract

The objective of the study was to study the protective effect of Silybum marianum check for this species in other resources extract on hepatic ischemia- reperfusion injury. Rats were randomly divided into five groups; namely Silybum marianum extract high-, medium-, and low- dose protection groups, model group and control group. Hepatic ischemia-reperfusion injury model was prepared. Serum or plasma AST, ALT, MDA, TNF-α, IL-1β, IL-6 levels were measured. The results revealed that after liver injury, AST, ALT, MDA, TNF-α, IL-1β, and IL-6 levels significantly increased in succession, showing significant differences. We concluded that inflammatory cytokines participate in liver injury and that Silybum marianum extract can reduce the production of inflammatory cytokines, and thus can have a protective effect on hepatic ischemia and reperfusion.

Keywords
Silybum marianum; hepatic ischemia-reperfusion injury; protective effect

 
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