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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 5, 2013, pp. 318-324
Bioline Code: tc13122
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 5, 2013, pp. 318-324

 en A STUDY ON INHIBITORY EFFECT OF SPICA PRUNELLAE check for this species in other resources EXTRACT ON T LYMPHOMA CELL EL-4 TUMOUR
Mao, Xingjiang; Wang, Gengfu; Zhang, Wei & Li, Shaoping

Abstract

The objective of the study was to investigate the in-vivo anti-tumour activity of Spica prunellae check for this species in other resources extract, and to preliminarily explore the possible mechanism of in-vivo anti-tumour effect of Spica prunellae extract. Tumour inhibition rate and tumour apoptosis-related protein status were determined using the mice model of transplanted T lymphoma cell EL-4 tumour, and by immunohistochemical method. The results revealed that Spica prunellae extract showed certain tumour inhibitory effect, and compared with the model group. Tumour weight in Spica prunellae high-dose group was highly significantly different (P<0.01). Tumour weight in Spica prunellae medium-dose group was also significantly different (P<0.05) compared with the model group. Spica prunellae high-dose group enabled the high expression of Bcl-2 protein (47.54%) and low expression of Bax protein (13.14%). The study concluded that Spica prunellae extract has certain in vivo anti-tumour effect, which may be achieved through regulation of apoptosis related proteins.

Keywords
Spica prunellae; EL-4 solid tumour; tumour inhibition; mechanism

 
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