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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 6, 2013, pp. 456-458
Bioline Code: tc13148
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 6, 2013, pp. 456-458

 en STUDY ON OPTIMISATION OF EXTRACTION PROCESS OF TANSHINONE IIA AND ITS MECHANISM OF INDUCTION OF GASTRIC CANCER SGC7901 CELL APOPTOSIS
Hou, Jianhong; He, Jiantai; Jin, Xin; Hu, Tian & Zhang, Yangde

Abstract

The objective of this paper was to investigate the extraction process of tanshinone IIA and its mechanism of induction of gastric cancer SGC7901 cell apoptosis. Extraction process of tanshinone IIA was optimised by orthogonal experimental method, and its effect on gastric cancer SGC7901 cell apoptosis was observed using MTT assay and electron microscopy. The optimum extraction process of tanshinone IIA was as follows: addition of a 10-fold amount of 80% ethanol, one-time extraction, and extraction time of 45 minutes. The study concluded that tanshinone IIA can induce apoptosis of gastric cancer SGC7901 cells.

Keywords
Tanshinone II A; MTT assay; gastric cancer SGC7901 cells

 
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