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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 6, 2013, pp. 490-493
Bioline Code: tc13155
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 6, 2013, pp. 490-493

 en EFFECT OF ETHANOL EXTRACT OF SELAGINELLA DOEDERLEINII HIERON check for this species in other resources ON THE PROLIFERATION OF NASOPHARYNGEAL CARCINOMA CNE-1 AND C666-1 CELLS
Lian, Rong; Li, Jing; Ma, Hui-Min; Zhang, Guo-Zheng; Guo, Xi-Ai; Li, Xiao & Yang, Jian-Bin

Abstract

This paper mainly studied the effect of ethanol extract of Selaginella doederleinii Hieron check for this species in other resources on the proliferation of two kinds of nasopharyngeal carcinoma cell lines, CNE-1 and C666-1, and their mechanisms of action. Extract was obtained by heat reflux extraction with ethanol, and the effect of extract on the extracellular matrix adhesion of the cells, on their proliferation process, as well as on their colony-forming ability were tested using MTT assay. The results showed that the yield of dry extract was 36.4%. 2.5 g/ml extract in the high concentration group exhibited inhibitory activity that was directly proportional to the concentration on CNE-1 cells, while not exhibiting obvious proportional trend in respect with C666-1 cells. However, the inhibition rates against two types of cells can both reach between 30%~50%. Under the effect of ethanol extract of Selaginella doederleinii Hieron, proliferative capacities of C666-1 and CNE-1 cells were affected to some extent.

Keywords
Selaginella doederleinii Hieron; Ethanol extract; CNE-1; C666-1

 
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