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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 10, No. 6, 2013, pp. 542-546
Bioline Code: tc13164
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 10, No. 6, 2013, pp. 542-546

 en ANTICANCER EFFECTS OF LIGUSTICUM CHUANXIONG check for this species in other resources HORT ALCOHOL EXTRACTS ON HS766T CELL
Xie, Xu; Tian, Ye; Yin, Shuo; Lin, Yao & Tan, Guang

Abstract

This research was mainly to study the optimisation of extraction process of Ligusticum chuanxiong check for this species in other resources Hort alcohol extracts. Stable passage pancreatic cancer HS 766 T cell lines were created by cell culture, and the cell proliferation data were measured by MTT assay. The determination of HS766T cell cycle and apoptosis case was done by PI staining and flow cytometry analysis. The results displayed that Ligusticum chuanxiong Hort can inhibit the proliferation of pancreatic cancer HS 766 T cells. The cell cycle was blocked in G0/G1 phase, and the cell membrane was damaged on observation with microscope. At the same time, the generation of apoptosis was promoted by reduced intracellular Ca2+ concentration. All in all, the HS 766 T cells could be effectively suppressed by Ligusticum chuanxiong Hort alcohol extracts.

Keywords
Ligusticum chuanxiong Hort; HS766T; calcium concentration; cell cycle

 
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