There are strong beliefs in the efficacy of traditional medical systems worldwide. Many herbs have been acclaimed to possess
antiulcer effects and could be unexplored sources of new lead compounds. Sida corymbosa
R. E. Fries (Malvaceae) is used in Northern Nigeria to
treat ulcers and wounds. This work aimed to investigate the usefulness of Sida corymbosa
in treatments of stomach ulcers and wounds in
Materials and Methods:
Effect of the aqueous extract was determined on gastric ulceration, rate of wound healing and inflammation using
ethanol-induced and diclofenac-induced ulceration, wound excision model and albumin-induced inflammation respectively in rats.
The study demonstrated the anti-ulcer activity of Sida corymbosa
as the extract (250, 500 and 1000 mg/kg) showed a dose-dependent,
significant (P<0.05) reduction of ulcer indices against gastric ulcers induced by both ethanol and diclofenac. Topical application of a formulation
prepared with the extract of Sida corymbosa
on surgically created incisions produced an increase in the rate of healing of the wounds. The extract
of Sida corymbosa
exhibited a significant (P < 0.05), dose-related decrease in inflammation induced by fresh egg albumin. This study showed that
has constituents with the ability to reduce the severity of haemorrhagic gastric lesions, promote wound healing and reduce
inflammation. These actions may be attributed to any one of the active constituents or as a result of synergistic effects of these phytoconstituents.
This study validates the use of the plant in traditional medicine for the treatment of stomach ulcers and wounds.