African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
Vol. 11, No. 1, 2014, pp. 140-147
Bioline Code: tc14022
Full paper language: English
Document type: Research Article
Document available free of charge
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 11, No. 1, 2014, pp. 140-147
© Copyright 2014 - African Journal of Traditional, Complementary and Alternative Medicines
ASSESSMENT OF THE ANTI-DIARRHEA FUNCTION OF COMPOUND CHINESE HERBAL MEDICINE CANGPO ORAL LIQUID|
Xia, Xinchao; Wang, Hui; Niu, Xu; Wang, Haijun; Liu, Zhiqi; Liu, Yongming; Qi, Zhiming; Wang, Shengyi; Liu, Shixiang & Liu, Shanshan
Background: Diarrhea is a big problem in piglets. Cangpo Oral Liquid (COL) is a compound of Chinese herbal medicine. The preparation was
fed to piglets had diarrheal disease in order to determine its anti-diarrhea activity and potential applications in vivo.
Materials and Methods: The contents of Berberine hydrochloride, Magnolol and Honokiol in COL were performed on HPLC analysis. Organ
bath was used to investigate the effect of COL on peristaltic reflexes and peristaltic waves in vitro. And anti-diarrhea activity of COL was
evaluated in clinical.
Results: Thin layer chromatography (TLC) and HPLC analyses showed that the contents of Berberine hydrochloride, Magnolol and Honokiol in
COL were 970μg/mL, 130μg/mL and 300μg/mL, respectively. Administration of the COL to the organ bath caused a concentration-dependent
inhibition of intestinal peristalsis. When the COL concentration in the bath was cumulatively increased, the amplitude and frequency of the
peristaltic waves was lowered. The result of clinical efficacy of COL was very effective to diarrheic piglets. COL can possibly inhibit the curve of
peristaltic waves in vitro; and clinical trial showed a statistically significant therapeutic effect in vivo.
Conclusion: In conclusion, COL can be used as an effective therapeutic agent. However, the ingredients, pharmacokinetics and specific signaling
pathways of COL need to be further studied.
Cangpo Oral Liquid; therapeutic effect; peristalsis; herbal
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