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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 11, No. 1, 2014, pp. 161-164
Bioline Code: tc14025
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 11, No. 1, 2014, pp. 161-164

 en STUDY ON THE ANTI-CEREBRAL ISCHEMIA EFFECT OF BORNEOL AND ITS MECHANISM
Kong, Qing-xia; Wu, Zhao-ying; Chu, Xu; Liang, Ru-qing; Xia, Min & Li, Lei

Abstract

Background: Borneol is the processed item from resin of Dryobalanops aromatica check for this species in other resources Gaertn. f. It can enhance the activity of antioxidant enzymes in brain tissue and reduce inflammatory response by improving the energy metabolism of ischemic brain regions, and thereby reduces brain tissue damage. The objective of this paper was to study the anti-cerebral ischemia effect of borneol and its mechanism.
Materials and Methods: The anti-cerebral ischemia effect of borneol was studied by ligation of bilateral common carotid arteries (CCA), and vagus nerves in mice and the acute cerebral ischemia-reperfusion experiment in rats.
Results: Compared with the blank and solvent control groups, the borneol low-; medium-; and high-dose groups can significantly prolong the gasping time of mice after decapitation, and extend the survival time of mice after ligation of bilateral CCA, and vagus nerves.
Conclusion: Compared with the Xueshuantong injection group, the prolongation of survival time of mice after ligation of bilateral CCA, and vagus nerves was more apparent in the high-dose borneol experimental group; each experimental group can significantly reduce the number of leukocyte infiltration, the number of ICAM-1-positive vessels, as well as the number of TNF-α-positive cells.
Conclusion: Borneol has an anti-cerebral ischemia effect.

Keywords
borneol; cerebral ischemia-reperfusion; IL-1β; TNF-α; ICAM-1

 
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