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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 11, No. 1, 2014, pp. 172-175
Bioline Code: tc14027
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 11, No. 1, 2014, pp. 172-175

 en STUDY ON THE INHIBITORY EFFECT OF TOTAL ALKALIODS OF SOPHORA ALOPECUROIDES check for this species in other resources ON OSTEOSARCOMA CELL GROWTH
Lu, Xiang; Lin, Bin; Tang, Jia-guang; Cao, Zheng & Hu, Yuan

Abstract

Background: Ku Dou Zi is the dried whole plant, roots and seeds of Sophora alopecuroides check for this species in other resources L. in the genus Sophora of family Leguminosae. The entire plant is bitter in taste, cold in nature, and has the heat clearing, detoxifying, pathogenic wind dispelling dampness, analgesic, and insecticidal effects. Modern pharmacological studies have proved that TASA has pharmacological activities of anti-cancer. The objective of this paper was to investigate the inhibitory effect of total alkaloids of Sophora alopecuroides (TASA), on osteosarcoma cell growth and its mechanism.
Materials and Methods: MTT assay and flow cytometry were used to study the inhibitory effect of TASA on human osteosarcoma cell line OS732.
Results: The results showed that the inhibition rates of different concentrations of TASA (1.5, 3, and 4.5g/kg), against human osteosarcoma cell line OS732, were: 18.4%, 27.4% and 52.8%, respectively.
Conclusion: TASA has an inhibitory effect on osteosarcoma cell growth.

Keywords
total alkaloids of Sophora alopecuroides; human osteosarcoma cell line OS732; flow cytometry

 
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