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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 11, No. 2, 2014, pp. 292-294
Bioline Code: tc14046
Full paper language: English
Document type: Short Communication
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 11, No. 2, 2014, pp. 292-294

 en INVESTIGATION ON ANTIDIARRHOEAL ACTIVITY OF ARISTOLOCHIA INDICA check for this species in other resources LINN. ROOT EXTRACTS IN MICE
Rajan Dharmalingam, Senthil; Madhappan, Rajkumar; Ramamurthy, Srinivasan; Chidambaram, Kumarappan; Venkata Srikanth, Meka; Shanmugham, Suresh & Kumar K. L., Senthil

Abstract

Background: The present study aimed at investigating the effect of ethanolic extract (EtAI), and aqueous extract (AqAI) of Aristolochia indica check for this species in other resources Linn roots on castor oil-induced diarrhoea and study on small intestinal transit. Phytochemical analysis of extracts was performed as per standard procedure.
Materials and Methods: The oral toxicity study using Swiss albino mice was performed in accordance with OECD guidelines. The EtAI and AqAI extracts of Aristolochia indica Linn were studied for antidiarrhoeal property using castor oil-induced diarrhoeal model and charcoalinduced gastrointestinal motility test in Swiss albino mice.
Results: Among the tested doses of 200 and 400 mg/kg body weight, the extracts reduced the frequency and severity of diarrhoea in test animals throughout the study period. At the same doses, the extract delayed the intestinal transit of charcoal meal in test animals as compared to the control and the results were statistically significant.
Conclusion: Experimental findings showed that ethanol extract of Aristolochia indica Linn root possess significant antidiarrheal activity and may be a potent source of anti-diarrhoeal drug in future.

Keywords
Antidiarrheal activity; Aristolochia indica Linn; ethanol extract; small intestinal transit

 
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