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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 11, No. 2, 2014, pp. 411-414
Bioline Code: tc14062
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 11, No. 2, 2014, pp. 411-414

 en EXPERIMENTAL STUDY ON THE OPTIMIZATION OF EXTRACTION PROCESS OF GARLIC OILAND ITS ANTIBACTERIAL EFFECTS
Guo, Yajie

Abstract

Background: Garlic oil which is the main active constituent of garlic has a wide range of pharmacological activities, and a broad antibacterial spectrum. It also has a strong anti-cancer activity, and can significantly inhibit a variety of tumors such as liver cancer, gastric cancer and colon cancer. The objective is to study the extraction process of garlic oil and its antibacterial effects.
Materials and Methods: CO2 Supercritical extraction was used to investigate the optimal processing conditions for garlic oil extraction; filter paper test and suspension dilution test were applied to determine the bacteriostatic action of garlic oil.
Results: In the CO2 supercritical extraction experiment, factors influencing the yield of garlic oil were: extraction pressure > extraction temperature > extraction time in descending order. Range analysis showed that the optimal experimental conditions for CO2 supercritical extraction of garlic oil were extraction pressure of 15 Mpa, temperature of 40 ℃, and duration of 1 h. Different concentrations of garlic oil could all inhibit the growth of Staphylococcus aureus check for this species in other resources , Escherichia coli check for this species in other resources and Bacillus subtilis check for this species in other resources , suggesting that garlic oil has an antibacterial effect.
Conclusion: The optimal experimental conditions for CO2 supercritical extraction of garlic oil were: extraction pressure of 15 Mpa, temperature of 40 ℃, and duration of 1 h; garlic oil has an antibacterial effect.

Keywords
garlic oil; CO2; supercritical extraction; Staphylococcus aureus; Escherichia coli; Bacillus subtilis

 
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