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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 11, No. 2, 2014, pp. 447-451
Bioline Code: tc14066
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 11, No. 2, 2014, pp. 447-451

 en HEPATOPROTECTIVE EFFECT OF CYMBOPOGON CITRATUS check for this species in other resources AQUEOUS EXTRACT AGAINST HYDROGEN PEROXIDE-INDUCED LIVER INJURY IN MALE RATS
Rahim, Muhammad Saleh; Taha, Ekhlass Muhi; Al-janabi, Muneef Saeb; Al-douri, Bushra Ismael; Simon, Kumar Das & Mazlan, Abd Gaffar

Abstract

Background: Cymbopogon Citratus check for this species in other resources (Poaceae) a tropical perennial herb plant that is widely cultivated to be eaten either fresh with food or dried in tea or soft drink has been reported to possess a number of medicinal and aromatic properties. This study aimed at evaluating the protective effects of C. citratus aqueous extract against liver injury induced by hydrogen peroxide (H2O2), in male rats.
Materials and Methods: Twenty-five rats were randomly divided into five different groups of five animals in each group; (1) Control. (2) Received H2O2 (0.5%) with drinking water. (3), and (4) received H2O2 and C. citratus (100 mg·kg-1 b wt), vitamin C (250 mg·kg-1 b wt) respectively. (5), was given C. citratus alone. The treatments were administered for 30 days. Blood samples were collected and serum was used for biochemical assay including liver enzymes activities, total protein, total bilirubin and malonaldehyde, glutathione in serum and liver homogenates. Liver was excised and routinely processed for histological examinations.
Results: C. citratus attenuated liver damage due to H2O2 administration as indicated by the significant reduction (p<0.05), in the elevated levels of ALT, AST, ALP, LDH, TB, and MDA in serum and liver homogenates; increase in TP and GSH levels in serum and liver homogenates; and improvement of liver histo-pathological changes. These effects of the extract were similar to that of vitamin C which used as antioxidant reference.
Conclusion: C. citratus could effectively ameliorate H2O2-induced oxidative stress and prevent liver injury in male rats.

Keywords
Cymbopogon citratus; Vitamin C; Hydrogen peroxide; Rat; Liver enzymes; Serum proteins; Histopathology

 
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