Background: Bergenia purpurascens
has tonic, haemostatic and anti-tussive actions. Anti-inflammatory and anti-bacterial activities of Bergenia purpurascens
have not been reported so far. The objective of this paper is to provide experimental basis for the clinical application of Bergenia purpurascens
through the pharmacodynamic study on its anti-inflammatory and anti-bacterial effects.
Experimental models of xylene-induced ear edema in mice, cotton pellet granuloma in rats, and acetic acid-induced peritoneal capillary
permeability in mice were used to investigate the anti-inflammatory effect of Bergenia purpurascens
; bacteriostatic and bactericidal effects of
extract on Staphylococcus aureus
(SA), methicillin-resistant Staphylococcus aureus
(MRSA), and β-lactamase positive
(ESBLs-SA), were observed in vitro
The results show that Bergenia purpurascens
extract could markedly inhibit xylene-induced mouse ear edema, cotton pellet granulation
tissue hyperplasia, and increased capillary permeability. Bergenia purpurascens
extract has an inhibitory effect on SA, MRSA and ESBLs-SA.
We conclude that Bergenia purpurascens
extract has certain anti-inflammatory and anti-bacterial effects.