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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 11, No. 2, 2014, pp. 469-474
Bioline Code: tc14070
Full paper language: English
Document type: Editorial
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 11, No. 2, 2014, pp. 469-474

 en ELECTROACUPUNCTURING AT ZUSANLI POINT (ST36) ATTENUATES PRO-INFLAMMATORY CYTOKINE RELEASE AND ORGAN DYSFUNCTION BY ACTIVATING CHOLINERGIC ANTI-INFLAMMATORY PATHWAY IN RAT WITH ENDOTOXIN CHALLENGE
Song, Qi; Hu, Sen; Wang, Haibin; Lv, Yi; Shi, Xian; Sheng, Ziyong & Sheng, Wei

Abstract

Background: It is considered that the pathogenesis is closely related to an excessive production of pro-inflammatory cytokines caused by bacterial toxins and an imbalance between pro-inflammatory and anti-inflammatory mediators
Materials and Methods: This work investigates the effect of electro-acupuncturing (EA), at Zusanli point (ST36) on plasma cytokine release and organ dysfunction and their mechanism in conscious rats with endotoxin challenge.
Results: EA at Zusanli points obviously lowered the elevated levels of plasma TNF-α, and attenuated changes in parameters relevant to various organ functions at 2 h after LPS challenge. ɑ-BGT injection or bilateral cervical vagotomy could weaken or eliminate the effects of EA, and further aggravated the elevated levels of pro-inflammatory cytokines and organ dysfunction.
Conclusion: The results suggested that EA at Zusanli points significantly reduced the release of pro-inflammatory cytokines and organ dysfunction after LPS challenge by activating cholinergic anti-inflammatory pathway.

Keywords
Electro-acupuncture; Lipopolysaccharide; Cytokine; Cholinergic; anti-inflammatory pathway

 
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