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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 11, No. 3, 2014, pp. 1-6
Bioline Code: tc14073
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 11, No. 3, 2014, pp. 1-6

 en EFFECT OF EUPHORBIA CYPARISSIAS check for this species in other resources OINTMENTS ON ACANTHOSIS
Cristina, Romeo T.; Dumitrescu, Eugenia; Brezovan, Diana; Muselin, Florin & Chiurciu, Viorica

Abstract

Background: A pharmaco-chemical investigation of the Euphorbia cyparissias check for this species in other resources plant was justified by its known multiple therapeutic valences. Numerous components from extracts and latex of Euphorbiacae were identified, revealing a large plant family with a polyvalent therapeutic activity.
Materials and Methods: The aim of the study was to assess the skin tolerance level to irritation on different testing concentrations, of Euphorbia cyparissias extracts and ointments. Study was accomplished in rats and dogs, with the identification of all possible skin injuries and histological changes, after a simple patch test methodology.
Results: Ointment dermatological testing on rats, proved to be bearable on epilated skin at concentrations of 1, 2 and 5%. Ointments and mother tincture with higher concentrations (10% and 20%), led to irritation and cutis damages, and this was revealed through histology.
Conclusion: Ointment tested on dog’s skin was tolerable for epilated skin to concentrations of 1, 2 and/or 5%, additional testing on human volunteers confirmed the same situation.

Keywords
Acanthosis; Euphorbia cyparissias; ointments; rat; dog; dermatology test

 
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