MORIN, A FLAVONOID, ON LIPID PEROXIDATION AND ANTIOXIDANT STATUS IN EXPERIMENTAL MYOCARDIAL ISCHEMIC RATS|
Al-Numair, Khalid S.; Chandramohan, Govindasamy; Alsaif, Mohammed A.; Veeramani, Chinnadurai & El Newehy, Ahmed S.
Background: Myocardial infarction affects a large population in the world. Lipid peroxide metabolism plays an important role in the
pathology of myocardial infarction. Objective: The present study was designed to investigate the antioxidant potential of morin, a flavonoid in
isoproterenol (ISO)-induced myocardial infarction (MI), in rats.
Materials and Methods: Male albino Wistar rats were pre-treated with morin (40
mg/kg), daily for a period of 30 days. After the treatment period, ISO (85 mg/kg), was subcutaneously injected in rats at an interval of 24 h for 2
Results: ISO-administered rats showed elevated levels of thiobarbituric acid reactive substances (TBARS), and lipid hydro-peroxide
(LOOH), in plasma and heart. Pretreatment with morin, the above changes were significantly reduced to near normal level. ISOadministered
rats showed decrease in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and
glutathione-S-transferase (GST) in heart. In addition, decrease the levels non enzymatic antioxidants such as reduced glutathione (GSH), vitamin C
and vitamin E in plasma and heart while ceruloplasmin in plasma.
Conclusion: Pretreatment with morin, reversed these above biochemical
changes towards normalcy. These findings revealed that, the morin possess antioxidant activity in experimentally induced cardiac toxicity.
Morin; Isoproterenol; Myocardial infarction; Lipid peroxidation; Antioxidants