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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 11, No. 3, 2014, pp. 107-111
Bioline Code: tc14088
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 11, No. 3, 2014, pp. 107-111

 en ANTIOXIDANT ACTIVITIES AND TYROSINASE INHIBITION EFFECTS OF PHALERIA MACROCARPA check for this species in other resources EXTRACTS.
Nadri, Muhammad Helmi; Salim, Yushatika; Basar, Norazah; Yahya, Azli & Zulkifli, Razauden Mohamed

Abstract

Background: The ethyl acetate and chloroform extracts of stems, leaves and fruits of Phaleria macrocarpa check for this species in other resources were screened for their antioxidant capacity and tyrosinase inhibition properties.
Material and Method: The total phenolic content (TPC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and ferric-ion reducing power (FRAP) were used to evaluate their antioxidant capacity. Tyrosinase inhibition effect was measured using mushroom tyrosinase inhibition assay.
Result: Ethyl acetate extract of P. macrocarpa’s stem exhibited highest total phenolic content, DPPH free radical scavenging and ferric reducing power. Meanwhile, chloroform extracts of leaves and fruits demonstrated potent anti-tyrosinase activities as compared to a well-known tyrosinase inhibitor, kojic acid.
Conclusion: Since chloroform extracts of leaves and fruits have low antioxidant capacities, the tyrosinase inhibition effect observed are antioxidant independent. This study suggests direct tyrosinase inhibition by chloroform extracts of Phaleria macrocarpa.

Keywords
Phaleria macrocarpa; Antioxidant; Total phenolic content; Tyrosinase inhibition

 
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