search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 11, No. 3, 2014, pp. 124-131
Bioline Code: tc14091
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 11, No. 3, 2014, pp. 124-131

 en ANTIBACTERIAL AND ANTI-BIOFILM ACTIVITY OF FLAVONOIDS AND TRITERPENES ISOLATED FROM THE EXTRACTS OF FICUS SANSIBARICA check for this species in other resources WARB. SUBSP. SANSIBARICA (MORACEAE) EXTRACTS
Awolola, Gbonjubola V.; Koorbanally, Neil A.; Chenia, Hafizah; Shode, Francis O. & Baijnath, Himansu

Abstract

Background: Ficus check for this species in other resources species are used in African traditional medicine in the treatment of a wide variety of ailments and diseases such as convulsive disorder, wound healing, gonorrhea, tuberculosis, diabetes, diarrhoeal infections, dysentery, malaria and HIV. The aim of this study was to isolate the phytochemical constituents in the plant and test them for their antibacterial activity.
Materials and Methods: The fruits, leaves and stem bark were extracted with organic solvents and the compounds in the extracts separated and purified by column chromatography before being identified by NMR spectroscopy and by comparison of the NMR data against values reported in the literature. The antibacterial activity of the pure compounds and extracts were tested using the disk diffusion method.
Results: Three triterpenes and three flavonoids: lupeol acetate (1); cycloart-23-ene-3,25-diol (2); β-sitosterol (3); 5,7,4'-trihydroxyflavan-3-ol (4); epicatechin (5); and isovitexin (6) were isolated in this study. Antimicrobial activity was observed at 8 mg mL-1 for Staphylococcus aureus check for this species in other resources ATCC 29213 with four of the six isolated compounds, with no activity being observed at 1 – 4 mg mL-1 against Escherichia coli check for this species in other resources ATCC 25922, E. coli ATCC 35218 and S. aureus ATCC 43300. Epicatechin (5) was found to decrease adhesion of E. coli ATCC 25922 and S. aureus ATCC 29213. Decreased adhesion of S. aureus ATCC 29213 was also observed with 5,7,4'-trihydroxyflavan-3-ol (4) and isovitexin (6).
Conclusions: The results of this study provide baseline information on F. sansibarica’s check for this species in other resources potential validity in the treatment of infections associated with Gram-positive microorganisms.

Keywords
Moraceae; Ficus sansibarica; antimicrobial; anti-adhesion properties; flavonoids; triterpenoids

 
© Copyright 2014 - African Journal of Traditional, Complementary and Alternative Medicines
Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2017, Site last up-dated on 05-Dec-2017.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil