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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 11, No. 3, 2014, pp. 268-274
Bioline Code: tc14109
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 11, No. 3, 2014, pp. 268-274

 en COMPARATIVE ANTI-INFLAMMATORY AND HEPATOPROTECTIVE ACTIVITIES OF ASTRAGALUS GUMMIFER check for this species in other resources LABILL HERB AND ROOTS IN RATS
Yusufoglu, Hasan Soliman; Alam, Aftab; Zaghloul, Ahmed Mohammed; Al-salkini, Mohammad Ayman & Alam, Prawez

Abstract

Background: The Astragalus gummifer check for this species in other resources (F. Fabaceae), herb and roots were studied for anti-inflammatory and hepatoprotective activities.
Materials and method: The alcoholic extracts of Astragalus gummifer (F. Fabaceae), herb (AGHE), and roots (AGRE), were used for antiinflammatory and hepatoprotective activities in Wister rats. The effects of AGHE and AGRE were compared with the standard drugs Phenylbutazone and silymarin, for anti-inflammatory and hepatoprotective activities respectively.
Result: Both extracts showed significant anti-inflammatory activity (P< 0.001). AGRE showed comparatively more significant hepatoprotective activity (P< 0.001), than AGHE (P< 0.05); at doses of 250 and 500 mg/kg body weight as manifested by lowering the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and total bilirubin. The hepatoprotective activity was, also, supported by total protein (TP), malondialdehyde (MDA), nonprotein sulfhydryls (NP-SH), and histo-pathological studies of liver tissue.
Discussion: To the best of our knowledge, this is the first report of the anti-inflammatory and hepatoprotective activities of Astragalus gummifer. The results of present studies indicated that both AGHE and AGRE can be used in inflammatory conditions, while investigation supports the use of AGRE in cases that hepatoprotection are required in the hepatotoxic conditions. More supportive studies are required before clinical recommendation.

Keywords
Astragalus gummifer; Anti-inflammatory; Hepatoprotective; CCl4; carrageenan; Biochemical

 
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