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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 11, No. 4, 2014, pp. 142-146
Bioline Code: tc14135
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 11, No. 4, 2014, pp. 142-146

 en EVALUATION OF THREE MEDICINAL PLANT EXTRACTS AGAINST PLASMODIUM FALCIPARUM AND SELECTED MICROGANISMS
Falodun, Abiodun; Imieje, Vincent; Erharuyi, Osayewenre; Ahomafor, Joy; Jacob, Melissa R.; Khan, Shabana I. & Hamann, Mark T.

Abstract

Background: A great revival of scientific interests in drug discovery has been witnessed in recent years from medicinal plants for health maintenance. The aim of this work was to investigate three Nigerian medicinal plants collected in Nigeria for their in vitro antiplasmodial and antimicrobial activities.
Materials and Methods: Extracts obtained from parts of Persea americana check for this species in other resources , Jatropha podagrica check for this species in other resources and Picralima nitida and their fractions were evaluated for in vitro antiprotozoal and antimicrobial activity.
Result: The methanol extract of P. nitida demonstrated activity against chloroquine-sensitive and chloroquine-resistant P. falciparum clones with IC50 values of 6.3 and 6.0 μg/mL, respectively. Methanol and chloroform extracts of P. americana seed showed antifungal activity against Cryptococcus neoformans check for this species in other resources IC50 less than 8 and 8.211 μg/mL respectively. Finally, the petroleum ether extract of P. americana had activity against methicillinresistant Staphylococcus aureus check for this species in other resources (MRSA) with an IC50 value of 8.7 μg/mL.
Conclusion: The study revealed the antibacterial and antiplasmodial activities of the plants extracts at the tested concentrations.

Keywords
Antifungal; Antibacterial; Persea americana; Picralima nitida; Jatropha podagrica; Plasmodium falciparum

 
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