A great revival of scientific interests in drug discovery has been witnessed in recent years from medicinal plants for health maintenance.
The aim of this work was to investigate three Nigerian medicinal plants collected in Nigeria for their in vitro
antiplasmodial and antimicrobial
Materials and Methods:
Extracts obtained from parts of Persea americana
, Jatropha podagrica
and Picralima nitida
and their fractions were
evaluated for in vitro
antiprotozoal and antimicrobial activity.
The methanol extract of P. nitida
demonstrated activity against chloroquine-sensitive and chloroquine-resistant P. falciparum
clones with IC50
values of 6.3 and 6.0 μg/mL, respectively. Methanol and chloroform extracts of P. americana
seed showed antifungal activity against Cryptococcus
less than 8 and 8.211 μg/mL respectively. Finally, the petroleum ether extract of P. americana
had activity against methicillinresistant
(MRSA) with an IC50
value of 8.7 μg/mL.
The study revealed the antibacterial and antiplasmodial activities of the plants extracts at the tested concentrations.