Background: Antioxidants are of great importance for preventing oxidative stress that may cause several degenerative diseases. Studies have
indicated phytochemicals have high free-radical scavenging activity, which helps to reduce the risk of chronic diseases. The aim of the present
study is the determination of antioxidant properties, polyphenolic content and multidrug resistant bacteria of
Salvia verticcilata
L.
Materials and Methods: Methanol was used as the extraction solvent. The total phenolic content was calculated using Folin-Ciocalteau
method and phenolic composition was determined by HPLC. The radical scavenging activity of plant was evaluated
in vitro based on the
reduction of the stable DPPH free radical. The reducing capacity was identified by using the FRAP method. The ability of
Salvia verticcilata L. to
increase the permeability of multidrug resistant bacterial cells was conducted by flow cytometric assay on
Listeria innocua
and
E-coli
.
Results: The amount of total phenolics was found to be 347.5 mg GA/g extract. The IC
50 value and FRAP assay are 0.61, and 0.944
respectively, Free radical scavenging effect and FRAP values are less than synthetic antioxidant compounds (BHA and BHT). Eight phenolic
compounds were found in
Salvia verticcilata L. Intense concentration of
S. verticcilata L. has destroyed 97 % of living cells for
Listeria innocua
and 94.86% for
E-coli
Conclusion: This studyshows that methanolic extracts of
Salvia verticcilata L. is a potential source of natural antioxidants and antimicrobial
agent and can form the basis for pharmacological studies.
