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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 11, No. 5, 2014, pp. 83-90
Bioline Code: tc14151
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 11, No. 5, 2014, pp. 83-90

 en ANTIOXIDANT ACTIVITY AND INHIBITORY EFFECT OF SOME COMMONLY USED MEDICINAL PLANTS AGAINST LIPID PER-OXIDATION IN MICE BRAIN
Khan, Asmatullah; Nazar, Halima; Sabir, Syed Mubashar; Irshad, Muhammad; Awan, Shahid Iqbal; Abbas, Rizwan; Akram, Muhammad; Khaliq, Abdul; Rocha, João Batista Texeira; Ahmad, Syed Dilnawaz & Malik, Farnaz

Abstract

Background: The present study compares the protective properties of aqueous extracts of six medicinal plants, Phyllanthus emblica check for this species in other resources , Terminalia chebula check for this species in other resources (black and yellow), Terminalia arjuna, Balsamodendron Mukul and Alium sativum check for this species in other resources against lipid per-oxidation in mice brain.
Methods: The antioxidant activities were analyzed by lipid per-oxidation assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical assay, total antioxidant activity and metal chelation.
Results: The extracts (fruits and bark) showed inhibition against thiobarbituric acid reactive species (TBARS) induced by pro-oxidant (10 μM FeSO4) in mice brain. Moreover, the free radical scavenging activities of the extracts was evaluated by the scavenging of DPPH radical (IC50, 23.23±1.2 μg/ml (Phyllanthus emblica), 20.24±0.9 μg/ml (Terminalia chebula yellow) and 17.33±1.1 μg/ml (Terminalia chebula black), 19.44±0.45 ìg/ml (Terminalia arjuna), 56.59±2.1 μg/ml (Balsamodendron Mukul) and <200 μg/ml (Alium sativum).
Conclusion: The higher antioxidant and inhibitory effect of Terminalia chebula black in this study could be attributed to its significantly higher phenolic content, Fe(II) chelating ability, reducing ability and free radical scavenging activity. Therefore oxidative stress in brain could be potentially prevented by the intake of these plants.

Keywords
Antioxidant activity; Balb c mice; iron chelation; phenolics; oxidative stress; medicinal plants

 
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