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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 11, No. 6, 2014, pp. 33-39
Bioline Code: tc14160
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 11, No. 6, 2014, pp. 33-39

 en NEURO-PROTECTIVE EFFECTS OF CROCIN ON BRAIN AND CEREBELLUM TISSUES IN DIABETIC RATS
ALTINOZ, Eyup; ONER, Zulal; ELBE, Hulya & VARDI, Nigar

Abstract

Background: Increase in free oxygen radicals and the disruption of defense system make the neurons and astrocytes more sensitive against oxidative damage.
Materials and Methods: Rats were divided into three groups containing 10, rats in each group namely: control (C) group, Diabetes Mellitus (DM) group, and Diabetes Mellitus + crocin (DM+crocin) group. Tissue samples were processed by routine histological and biochemical procedures. The sections were stained with Hematoxylen-eosin. Malondialdehyde (MDA), glutathione (GSH), blood glucose, HbA1c levels and xanthine oxidase (XO) activities were assayed.
Results: The histological appearence of the cerebrum and cerebellum were normal in the control group. DM group showed some histopathological changes including congestion, perivascular and perineuronal edema in cerebrum. In DM + crocin group, histopathological changes in cerebrum and cerebellum markedly reduced. MDA level and XO activities increased significantly in DM group (P<0.01), but decreased significantly in DM + crocin group when compared to DM group (P<0.01). Blood glucose concentrations increased significantly (p<0.01) in DM group), but decreased significantly in DM + crocin group when compared with DM group (p<0.05). Blood HbA1c levels were normal in control group. But there were significant differences between control and DM groups (p<0.01). On the other hand, blood HbA1c levels decreased in DM+crocin group when compared with the DM group, but it was not statistically significant (p > 0.05).
Conclusion: Due to the fact that crocin has an antioxidant and anti-hyperglycemic effects, it can protect the brain and cerebellum tissue against the complications of oxidative stress.

Keywords
Diabetes mellitus; oxidative stress; crocin; brain; cerebellum

 
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