In ayurvedic and Thai traditional medicine, the fruit of T. chebula
is useful in arthritic disorders, inflammation, tumor, pains, chronic
and recurrent fever. The study investigated the analgesic and anti-inflammatory activities in animal models.
Materials and Methods:
The water extract of T. chebula
fruit was prepared and pain induced in mice by 0.1% formalin, before testing for the
analgesic activity of the extract. The anti-inflammatory study was conducted in rats using four experimental models; ethyl phenylpropiolate or
arachidonic acid-induced ear edema, carrageenan-induced paw edema and cotton pellet-induced granuloma formation.
The T. chebula
extract decreased licking times in mice injected with 0.1% formalin in both the early and late phases. Moreover, the extract
inhibited rat ear edema induced by ethyl phenylpropiolate as well as in carrageenan-induced paw edema. In contrast, the extract did not have any
inhibitory effect on arachidonic acid-induced ear edema in rats. The T. chebula
extract did not reduce granuloma weight, body weight gain and thymus
dry weight in cotton pellet-induced granuloma formation.
These results likely suggest that T. chebula
water extract possess both analgesic and anti-inflammatory activities. The main mechanisms
of action of T. chebula
water extract may be due to the inhibitory effect on the synthesis and/or release of pain or inflammatory mediators