Despite the rapidly changing concept of gastric ulcer management from conventional vagotomy, H2
receptor antagonists and antacids to
proton pump inhibitors, gastrointestinal toxicity remains an impediment to their application in clinical practice. Combined administration of two or
more plant extracts with therapeutic efficacy may proffer solution to this menace. This study investigated the combined gastroprotective effects of
and Ficus exasperata
leaf extracts against indomethacin-induced gastric ulcer in rats.
Materials and Methods:
Thirty rats were randomized into six groups of five animals each and ulceration was induced by a single oral administration
of indomethacin (30 mg/kg body weight). Ulcerated rats were orally administered with Spondias mombin
, Ficus exasperata
at 200 mg/kg body weight
and esomeprazole (a reference drug) at a dose of 20 mg/kg body weight once daily for 21 days after ulcer induction. At the end of the experiment,
gastric secretions and antioxidant parameters were evaluated.
We observed that the significantly increased (P < 0.05) ulcer index, gastric acidity, malondialdehyde level and pepsin activity were markedly
reduced following co-administration of S. mombin
and F. exasperata
. The extracts also effectively attenuated the reduced activities of superoxide
dismutase and catalase as well as pH, mucin content and reduced glutathione level in the ulcerated rats.
Discussion and Conclusion:
These findings are indicative of gastroprotective and antioxidative attributes of the two extracts which is also evident in
the % protective index value obtained. The available evidences in this study suggest that the complementary effects of S. mombin
and F. exasperata
proved to be capable of ameliorating indomethacin-mediated gastric ulceration and the probable mechanisms are via antioxidative and proton pump