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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 12, No. 1, 2015, pp. 99-103
Bioline Code: tc15014
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 12, No. 1, 2015, pp. 99-103

 en EVALUATION OF ACUTE TOXICITY AND ANTI-INFLAMMATORY EFFECTS OF BACCHAROIDES SCHIMPERI check for this species in other resources (DC.) IN EXPERIMENTAL ANIMALS
Ahmed, Sarfaraz; Ahmad, Mohammad S.; Yousaf, Muhammad; Mothana, Ramzi A. & Al-Rehaily, Adnan J.

Abstract

Background: Steroidal and non-steroidal anti-inflammatory drugs are most commonly used to treat inflammation, and shown to have severe side effects. In this study, we aimed at evaluating the anti-inflammatory and acute toxicity effects of Baccharoides schimperi check for this species in other resources (DC.) in order to get new anti-inflammatory agents of natural origin.
Materials and Methods: The aerial part of the plant was dried under shade, ground and extracted with 96% alcohol (BSE). It was further fractionated in sequence to n-hexane (BSH), chloroform (BSC) and methanol (BSM) soluble fractions. Acute toxicity was evaluated by oral administration of plant and hind paw induced-edema method in rats was used for the anti-inflammatory evaluation.
Results: The BSE was found safe up to the dose level of 3 g/kg b.w. and showed LD50 value 7.250 g/kg body weight (b.w.) in mice. BSE showed significant anti-inflammatory effect (62.91%) at 500 mg/kg b.w. Further the n-hexane, chloroform and methanol fractions of BSE were tested for antiinflammatory activity. The n-hexane fraction (BSH) exhibits significant activity (64.87%) at 400 mg/kg b.w. The methanol fraction (BSM) showed dose dependent activity, highest activity (60.42%) was observed at higher dose 400 of mg/kg b.w. In chloroform fraction (BSC) no significant activity was observed.
Conclusion: The results of the study revealed that the plant is safe to the experimental model and recommended as a potential source of antiinflammatory agent.

Keywords
Acute toxicity; anti-inflammatory activity; Baccharoide schimperi (DC.)

 
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