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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 12, No. 2, 2015, pp. 1-5
Bioline Code: tc15019
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 12, No. 2, 2015, pp. 1-5

 en HEPATOPROTECTIVE EFFECT AND GC-MS ANALYSIS OF TRADITIONALLY USED BOSWELLIA SACRA check for this species in other resources OLEO GUM RESIN (FRANKINCENSE) EXTRACT IN RATS
Asad, Mohammed & Alhumoud, Meshal

Abstract

Background: The water extract of oleo-gum-resin of Boswellia sacra check for this species in other resources Fleuckiger (Burseraceae) is used in the treatment of liver problems in the Middle East and Arab-African countries. The present study was carried out to evaluate its effect on liver injury induced by carbon tetrachloride in acute and chronic liver injury models.
Materials and Methods: The Boswellia sacra extract was administered at doses of 2 ml/kg and 5 ml/kg. Silymarin, a known hepato-protective agent was used as standard. The extract was subjected to GC-MS analysis to determine the presence of various phyto-constituents.
Results: The Boswellia sacra extract at tested doses of 2 ml/kg and 5 ml/kg significantly reduced the elevated serum levels of biomarkers in liver damage. The hepatoprotective effect was supported by changes in histopathology. The GC-MS analysis of the extract revealed the presence of several phyto-constituents that included menthol, 3-cyclohexen-1-ol and octanoic acid.
Conclusion: The water extract oleo-gum-resin of Boswellia sacra possesses hepatoprotective activity, as claimed by traditional healers within the Middle East and Arab-African countries.

Keywords
Boswellia sacra; hepatoprotective; carbon tetrachloride; frankincense; liver damage

 
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