African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
Vol. 12, No. 2, 2015, pp. 68-72
Bioline Code: tc15031
Full paper language: English
Document type: Short Communication
Document available free of charge
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 12, No. 2, 2015, pp. 68-72
© Copyright 2015 - African Journal of Traditional, Complementary and Alternative Medicines
THE INVESTIGATIONS OF TOTAL ANTIOXIDANT STATUS AND BIOCHEMICAL SERUM PROFILE IN THYMOQUINONE-TREATED RATS|
Kurt, E.; Dede, S. & Ragbetli, C.
Background: This study was planned to determine the dosage and duration of thymoquinone (TQ) at which it demonstrates the optimum effect
on the total antioxidant status (TAS) and the biochemical parameters in the blood serum.
Materials and Methods: 48 male rats (Wistar-albino) weighing between 200-250 g were used as material. Group 1 (control) (TQ solution 5
mg/kg/day), Group 2 (15 mg/kg/day), Group 3 (30 mg/kg/day), Group 4 (45 mg/kg/day) and Group 5 (60 mg/kg/day) were designated, each
containing 8 rats. Different doses of TQ (oral gavage) were administered for four weeks.
Results: The TAS levels were determined to be considerably low statistically in all TQ-administered groups in comparison with the control
group. It was determined that the serum biochemical parameters exerted a significant effect depending on the TQ doses.
Conclusion: As a result, rats administered with TQ orally, at 60 mg/kg dosage, show that the liver and kidney function parameters in particular as
different from normal. This brings us to the conclusion that at this dosage, there is reliable biochemical wise but future protective studies in which
30 mg/kg doses can be used safely is encouraged.
biochemical parameters; rat; thymoquinone; total antioxidant status (TAS)
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