African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
Vol. 12, No. 2, 2015, pp. 96-102
Bioline Code: tc15033
Full paper language: English
Document type: Research Article
Document available free of charge
African Journal of Traditional, Complementary and Alternative Medicines, Vol. 12, No. 2, 2015, pp. 96-102
© Copyright 2015 - African Journal of Traditional, Complementary and Alternative Medicines
ANTIPROLIFERATION EFFECTS OF SELECTED TANZANIA PLANTS|
Choi, Chun Whan; Song, Seok Bean; Oh, Joa Sub & Kim, Young Ho
Background: Plants still remain a prime source of drugs for the treatment of cancer and can provide leads for the development of novel
anticancer agents. Our screening of indigenous medicinal plants from Tanzania has led to the identification of the number of anticancer activity.
Material and methods: The current study investigates the cytotoxic activity of methanol extracts of one hundred and thirty seven Tanzania
plants used locally for the traditional medicine herb using the MTS assay on the HepG2 cell lines.
Result 16% of the tested plant extracts showed moderate to strong inhibitory activity with IC50 values ranging from 17.1 ± 1.1 μg/ml to 79.2 ±
0.7 μg/ml ; meanwhile, ten extracts (7.3%) could demonstrate cytotoxic activity with IC50 values less than 27.6 ± 2.0 μg/ml; twelve extracts
(8.8%) could demonstrate cytotoxic activity with IC50 values ranging from 30.4 ± 1.6 μg/ml to 79.2 ± 0.7μg/ml.
Conclusion : Especially, a methanol extract from the bark extract of Erythrophleum zimmermannii (Fabaceae) was found to be the most
cytotoxicity against HepG2 cell lines (IC50 = 17.1 ± 1.1 μg/ml).
Medicinal plants; Cytotoxicity; Erythrophleum zimmermannii (Fabaceae)
Alternative site location: http://journals.sfu.ca/africanem/index.php/ajtcam