This study investigated on antioxidant activity of Piper caninum
and cyclooxygenase-2 inhibition by methoxylated
Materials and methods:
The present study was carried out to quantify the total phenolic content and free radical scavenging activities of
the crude extracts by Folin-Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay respectively.
Methanolic extracts of Piper caninum
exhibited the highest total phenolic content and free radical scavenging activities. All the
pure compounds possessed significant cyclooxygenase-2 inhibition at physiological concentrations.
Based on in vitro
and molecular docking, we therefore suggest that Piper caninum
methoxylated flavones are potent
inhibitors of cyclooxygenase-2 at physiological concentrations