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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 12, No. 2, 2015, pp. 120-125
Bioline Code: tc15036
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 12, No. 2, 2015, pp. 120-125

 en ANTIOXIDANT ACTIVITY OF PIPER CANINUM check for this species in other resources AND CYCLOOXYGENASE-2 INHIBITION BY METHOXYLATED FLAVONES
Nadri, Muhammad Helmi; Naser, Mohammed Abu; Zukifli, Razauden Mohamed; Muhamad, Ida Idayu; Ahmad, Farediah; Wan Salleh, Wan Mohd Nuzul Hakimi & Sirat, Hasnah M.

Abstract

Background: This study investigated on antioxidant activity of Piper caninum check for this species in other resources and cyclooxygenase-2 inhibition by methoxylated flavones.
Materials and methods: The present study was carried out to quantify the total phenolic content and free radical scavenging activities of the crude extracts by Folin-Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay respectively.
Results: Methanolic extracts of Piper caninum exhibited the highest total phenolic content and free radical scavenging activities. All the pure compounds possessed significant cyclooxygenase-2 inhibition at physiological concentrations.
Conclusion: Based on in vitro and molecular docking, we therefore suggest that Piper caninum methoxylated flavones are potent inhibitors of cyclooxygenase-2 at physiological concentrations

Keywords
Piper caninum; antioxidant; cyclooxygenase-2.

 
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