Background: This study investigated on antioxidant activity of
Piper caninum
and cyclooxygenase-2 inhibition by methoxylated
flavones.
Materials and methods: The present study was carried out to quantify the total phenolic content and free radical scavenging activities of
the crude extracts by Folin-Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay respectively.
Results: Methanolic extracts of
Piper caninum exhibited the highest total phenolic content and free radical scavenging activities. All the
pure compounds possessed significant cyclooxygenase-2 inhibition at physiological concentrations.
Conclusion: Based on
in vitro and molecular docking, we therefore suggest that
Piper caninum methoxylated flavones are potent
inhibitors of cyclooxygenase-2 at physiological concentrations
